Acute Postoperative Pain
Conditions
Interventions
Experimental Group:In the study group, 10 mg of oliceridine injection was diluted in 40 ml of normal saline to prepare a 50 ml solution with a concentration of 0.2 mg/ml. An initial loading dose of 1.
Control Group:In the control group, 2 mg of remifentanil was diluted in 50 ml of normal saline to prepare a solution with a concentration of 40 µg/ml. An initial loading dose of placebo (normal saline
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 80 years old 2. Patients who need mechanical ventilation after abdominal surgery and are transferred to the ICU
Exclusion criteria
Exclusion criteria: 1. Severe cardiac dysfunction (NYHA IV grade), abnormal liver function (Child-Pugh C grade), abnormal kidney function (preoperative dialysis was performed), or ASA classification >= IV grade; 2. Allergy to opioid drugs; 3. Pregnant or lactating patients; 4. Severe hemodynamic instability (NE requirement > 0.5 µg/kg/min to maintain MAP >= 65 mmHg, or frequent malignant arrhythmias); 5. Chronic pain treated with long-term analgesic drugs; 6. QT interval on electrocardiogram: > 450 ms for males, > 470 ms for females; 7. Need to use muscle relaxants or deep sedation (RASS -5 to -3); 8. Patients with communication disorders; 9. Other situations deemed inappropriate for participation in the study by researchers or supervising doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of time within the target analgesic level (CPOT <=3) relative to the total study drug administration time.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of Patients with Sustained Target Analgesia;Time to onset and incidence rate of rebound pain;The proportion of patients receiving rescue analgesic medication.; | — |
Countries
China
Contacts
Public ContactKeliang Xie
Tianjin Medical University General Hospital
Outcome results
None listed