Sarcopenia
Conditions
Interventions
The group with sarcopenia observation:None
Sponsors
Shanghai No. 4 People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old, gender and ethnicity not restricted; 2. Patients who plan to undergo elective surgery under total intravenous general anesthesia; 3. ASA I-III grade; 4. Expected operation duration >= 1.5 hours (including our hospital's advantageous specialties such as trauma orthopedics, gastrointestinal surgery, hepatobiliary surgery, urology, and some high-risk groups); 5. Voluntary participation and signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1. Inability to participate in follow-up communication due to visual, auditory, language, or other impairments; 2. Intracranial tumor surgery or traumatic brain injury surgery; 3. Severe hepatic impairment (Child-Pugh class C); 4. Renal failure requiring renal replacement therapy; 5. Preoperative coma, sedation, psychiatric disorders, or dementia rendering communication impossible; 6. Participation in another drug trial within the past three months; 7. Patients who refuse to participate; 8. Other conditions deemed unsuitable for participation by the investigator (reasons must be documented);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in plasma Metrnl levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of sarcopenia in surgical patients;The incidence rate of PND in patients with sarcopenia;The hemodynamic stability during the operation;The usage of anesthetic drugs during the operation; | — |
Countries
China
Contacts
Public ContactTan Jingjing
Shanghai No. 4 People's Hospital
Outcome results
None listed