Spontaneous abortion
Conditions
Interventions
The metformin group:Take metformin orally (twice a day, 0.5g each time)
The inositol group:Take oral inositol (once a day, 0.5g each time)
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. 20 years old 2.6) 4. Before being included in the study, no treatment with metformin or inositol was administered for one month 5. No plans for pregnancy in the coming month 6. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1.Systemic infectious diseases; 2.Congenital uterine malformations (such as single-lobed uterus, double-lobed uterus, septate uterus, etc.); 3.Uncontrolled endocrine disorders; 4.Uncontrolled autoimmune diseases; 5.Abnormal liver function (bilirubin > 16 µmol/L, ALT > 60 IU/L) or abnormal kidney function (urea > 6.6 mmol/L, creatinine > 85 µmol/L, sodium > 145 mmol/L, potassium > 5.0 mmol/L);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early miscarriage rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| HOMA-IR;Incidence of adverse reactions;BMI;Incidence of Common Pregnancy Complications;Delivery Outcomes; | — |
Countries
China
Contacts
Public ContactHui Chen
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed