Moderate to severe carotid artery stenosis
Conditions
Interventions
Remimazolam group:Continuous infusion of remimazolam during surgery
Propofol group:Intraoperative continuous infusion of propofol
Sponsors
Hengshui People's Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients in our hospital who are confirmed by preoperative ultrasound or digital subtraction angiography (DSA) to have severe carotid artery stenosis, and are scheduled for elective carotid endarterectomy (CEA). (CEA surgical indications: symptomatic carotid stenosis of 50%–99%; asymptomatic carotid stenosis of 70%–99%); 2. No gender restriction, aged 35–80 years, BMI <30 kg/m²; 3. American Society of Anesthesiologists (ASA) classification II or III; 4. No severe hypertension or cardiovascular and cerebrovascular diseases; 5. No mental or neurological disorders and no cognitive dysfunction; 6. No liver, kidney, or coagulation function abnormalities.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal preoperative muscle strength examination, indicating damage to the limb conduction pathway, or those with contraindications to electrophysiological monitoring; 2. Patients allergic to the drugs used in the study; patients who have become addicted to long-term use of sedatives and analgesics; 3. Patients with communication disorders in terms of mental state, language, and hearing; 4. Carotid artery occlusion; 5. Patients who developed new cerebral infarction within 2 weeks before surgery, experienced ischemic stroke within 3 weeks before surgery, or had intracranial hemorrhage within 3 months before surgery; 6. Patients with serial vascular stenosis lesions or coexisting other diseases that may interfere with the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor evoked potentials;Somatosensory Evoked Potentials; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain oxygen saturation; | — |
Countries
China
Contacts
Public ContactWang Fuchao
Hengshui People's Hospital
Outcome results
None listed