Study on anesthetic sedative drugs
Conditions
Interventions
Cyclopophenol group:In the ciprofol group, induction was performed with slow intravenous injection of 1 µg/kg fentanyl (up to 50 µg) and 0.2 mg/kg ciprofol until the patient fell asleep and the eyelas
Remazolam group:In the remimazolam group, induction was performed with slow intravenous injection of 1 µg/kg fentanyl (up to 50 µg) and 0.2–0.3 mg/kg remimazolam. For maintenance of anesthesia, supple
Sponsors
Seventh Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years 2. Accept elective painless gastroscopy or colonoscopy or gastrointestinal endoscopy diagnosis and treatment 3.ASA grade I or II. 4.It is estimated that the operation time of gastrointestinal endoscopy not exceed 60 minutes. 5.Clear understanding, voluntary participation in this study, and signed informed consent
Exclusion criteria
Exclusion criteria: 1.Complicated endoscopic diagnosis and treatment techniques ( such as cholangiopancreatography, endoscopic mucosal resection, endoscopic submucosal dissection, transoral endoscopic myotomy, etc. ) ; 2.Patients undergoing tracheal intubation ; there are serious heart diseases such as severe arrhythmia, heart failure, A-S syndrome, unstable angina pectoris, myocardial infarction in the past 6 months, tachycardia / bradycardia history requiring drug treatment, and third-degree atrioventricular block ; 3.History of hypertension or admission measured systolic blood pressure >= 180mmHg or / and diastolic blood pressure >= 110mmHg ; 4.Respiratory insufficiency, history of obstructive pulmonary disease, history of bronchospasm requiring treatment within 3 months, acute respiratory tract infection within 1 week, and obvious symptoms such as fever, wheezing, nasal congestion and cough ; 5.There is an uncontrolled history of diseases with significant clinical significance, such as liver, kidney, blood system, nervous system or metabolic system, which the researchers determine may not be suitable for the study ; 6.Known allergies to eggs, bean products, benzodiazepines and their components, opioids and their rescue drugs ; 7.3 months had a history of alcoholism ; 8.Cerebral injury, possible convulsions, myoclonus, intracranial hypertension, cerebral aneurysms, cerebrovascular accident history ; 9.Schizophrenia, mental retardation, mania, mental disorders, myasthenia gravis, severe depression, long-term use of psychotropic drugs, drug addiction, cognitive dysfunction and other patients ; 10.Researchers believe that patients should not participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension ( systolic blood pressure < 90 mmHg or mean arterial pressure < 65 mmHg ); | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of hypotension value;Hypoxemia ( < 90 % );Incidence of injection pain;Induction time;Examination time;Anesthesia time;Recovery time;Patients satisfaction;Physician satisfaction; | — |
Countries
China
Contacts
Public ContactZhu Qianqian
Seventh Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed