Infertility
Conditions
Interventions
Experimental group:Starting from the 4th to 5th day of ovulation induction, oral dexamethasone 0.75 mg per day should be taken until the hCG administration day when the medication should be stopped.
Control group:Dexamethasone was not administered during the ovulation induction cycle.
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 1.2 ng/ml and antral follicle count (AFC) > 7; 3. This is the first time undergoing IVF/ICSI; 4. BMI < 30 kg/m^2; 5. Using modified flexible GnRH antagonist protocol.
Exclusion criteria
Exclusion criteria: 1. PGT cycle; 2. Recurrent miscarriage (intrauterine pregnancy spontaneous abortion >= 2 times); 3. Abnormal uterus: such as septate uterus, bicornuate uterus, unilocular uterus, double uterus, etc.; cervical conization after surgery or cervical insufficiency; uterine adenomyosis, history of intrauterine adhesions, submucosal uterine fibroids, uterine fibroids causing deformation of the uterine cavity; 4. Hydrosalpinx, without ligation or resection; 5. Known chromosomal abnormalities of one or both partners (excluding polymorphism); 6. Premature progesterone elevation (serum progesterone in the early stage of induction = 0.8 ng/ml); 7. Unrepaired internal and external diseases that may affect pregnancy: such as hypertension, heart disease with clinical manifestations, diabetes, hepatic insufficiency, renal insufficiency, severe anemia, previous thrombosis history, history of cerebrovascular disease, etc.; 8. Patients undergoing testicular sperm extraction or microscopic sperm extraction; 9. Unwilling to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HCG day progesterone level (the proportion of values greater than 0.8 ng/ml); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Premature LH surge incidence rate;Number of oocytes retrieved;Number of embryos obtained;Early pregnancy loss rate;Rate of ongoing pregnancy;Severe OHSS incidence rate;Live birth rate;Fresh cycle cancellation rate; | — |
Countries
China
Contacts
Public ContactXu Bei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed