Colorectal cancer, advanced colorectal adenoma
Conditions
Interventions
Colonoscopy Screening Group:Colonoscopy Screening
FIT group:FIT Screening
FIT plus blood test group:FIT?blood test
Sponsors
The second affiliated hospital of Zhejiang University school of medicine
Eligibility
Sex/Gender
All
Age
45 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Age: 45-74 years old; 2.In good general condition, with normal mental state and voluntarily signing the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Personal history of colorectal cancer or precancerous lesions; 2. History of previous colon resection surgery; 3. Diagnosed with cancer before enrollment or currently receiving any cancer-related treatment; 4. Having received colonoscopy, flexible sigmoidoscopy, CT colonography and other examinations within the past 5 years; 5. Having received FIT or FIT-sDNA or cfDNA test within the past 1 year; 6. Symptomatic lower gastrointestinal diseases or symptoms suggesting the need for diagnostic colonoscopy for confirmation; 7. Accompanied by severe diseases that are not suitable for colorectal cancer screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate of colorectal cancer at 10 years; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of colorectal cancer at 10 years;Proportion of colorectal cancer at different stages;Total cost and cost per detected lesion;Quality of life;Detection rate of advanced colorectal neoplasms (advanced adenomas + colorectal cancer);Population compliance rate;Incremental cost-effectiveness ratio; | — |
Countries
China
Contacts
Public ContactKefeng Ding
The second affiliated hospital of Zhejiang University school of medicine
Outcome results
None listed