After internal exposure to sunscreen products, accurately quantify the intake of their main components, their spatial distribution and metabolism within the skin, and their effects on organ function.
Conditions
Interventions
Single-Day Intervention Group:Use sunscreen
Long-term intervention group:Use sunscreen
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Signed and dated informed consent form; 2.Commit to adhering to research procedures and cooperating throughout the entire research process. 3.Healthy adult men and women aged 18 to 60; 4.BMI index between 18.5 and 29.9, and self-reported as not having sensitive skin. 5.No sunscreen products (including sunscreen, moisturizers, and other products containing SPF) have been used within the past two weeks. 6.Can adhere to and cooperate with product usage; 7.Women of childbearing potential must abstain from pregnancy for at least one month prior to screening and commit to using contraception throughout the study period and for a specified period after study completion.
Exclusion criteria
Exclusion criteria: 1.Patients with severe systemic diseases, or those currently using or having used systemic or topical corticosteroids, retinoids, vasoconstrictors, antibiotics, anti-inflammatory drugs, high-dose vitamin C, beta-carotene, etc., within one month prior to the start of this study. 2.Individuals with severe allergic conditions or a history of allergies, such as allergic dermatitis or allergic rhinitis. 3.Individuals who have experienced cosmetic allergies within the past year or have a history of allergic reactions to daily sunscreen products. 4.Sensitive Skin Questionnaire Score Exceeds 18 Points; 5.Individuals working outdoors who cannot avoid sun exposure; 6.The test area has undergone cosmetic procedures within the past two months. 7.History of skin conditions or other medical conditions that may affect trial results, as well as other circumstances that preclude the use of trial samples. 8.Currently participating in or having participated in other clinical trials within the past three months prior to the start of this study. 9.Pregnant women, breastfeeding mothers, or those planning to become pregnant; 10.Individuals who have taken oral contraceptives within the past three months and throughout the entire study period;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main component blood concentration;Skin Spatial Distribution;Changes in Endogenous Metabolism of the Skin;Questionnaires or other tools for reporting patient outcomes, such as diaries.; | — |
Countries
China
Contacts
Public ContactJie Zheng
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed