Adverse ueurological outcomes?
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >= 45 years and < 75 years. 2. Scheduled for elective thoracic, orthopedic, abdominal, or cardiac surgery under general anesthesia. 3. American Society of Anesthesiologists (ASA) physical status classification of I to III. 4. Willing to participate in the study and having provided signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hepatic or renal dysfunction, or acute myocardial infarction. 2. Current use of psychotropic medications. 3. History of alcohol or opioid abuse. 4. Inability to cooperate with the study procedures for any reason, or judged by the investigator as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fNIRS data;EEG data;Mini-mental state examination, MMSE;Patient health questionnaire-9, PHQ 9;Generalized anxiety disorder 7-item scale, GAD-7;Numerical rating scale, NRS;Richards-campbell sleep questionnaire, RCSQ;Modified Brice Questionnaire;Confusion assessment method for the Intensive care unit, CAM-ICU;Confusion assessment method, CAM;Quality of recovery-15 scale, QoR-15;Alzheimer’s disease 8-item informant questionnaire, AD-8;EuroSCORE;FRAIL Scale??;Neurological Complications??; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory Complications??;Gastrointestinal Complications;Urogenital Complications?;Hematologic Complications?;Endocrine Complications;Other Complications; | — |
Countries
China
Contacts
The Second Affiliated Hospital of Army Medical University