Hematological malignancies
Conditions
Interventions
Gold Standard:Bone marrow aspiration examination
Index test:The diagnostic test to be evaluated in this study is a blood routine data-driven multimodal model for the early diagnosis of hematologic neoplasms. This model takes relevant indicators of c
2.Original data/images of white blood cell scatter plots
3.Original data/images of reticulocyte scatter plots.
4.As an integrated diagnostic test method, this multimodal model realizes the early diagnostic evaluation of hematologic neoplasms by integrating
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria Case Group: 1.Aged >=18 years;Definite diagnosis of hematologic neoplasms in line with clinical gold standards; 2.Complete data of complete blood cell analysis before diagnosis (without any targeted treatment received), 3.Including numerical parameters and original data/images of white blood cell and reticulocyte scatter plots. Control Group: 1.Aged >=18 years; 2.Underwent examinations such as bone marrow aspiration due to suspected hematologic neoplasms, and malignant hematologic diseases were definitively ruled out by gold standards; 3.Complete routine blood numerical parameters and data of white blood cell and reticulocyte scatter plots before bone marrow aspiration.
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1.Severe missing or poor quality of routine blood numerical parameters or scatter plot data that renders them unfit for research analysis; 2.Having received treatments that may significantly affect routine blood test results (e.g., chemotherapy, radiotherapy, targeted therapy, stem cell transplantation) prior to the diagnosis of hematologic neoplasms; 3.Combined with known severe non-hematological infections (such as sepsis), severe renal failure, bone marrow metastasis of solid tumors, pregnancy, and other diseases or conditions that significantly interfere with blood routine and scatter plot manifestations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete blood count numerical parameters (DIFF);White blood cell scatter plot raw data (WBC);Accuracy;Precision;Recall (Sensitivity);Specificity; | — |
Countries
China
Contacts
Public ContactZheng Qin
West China Hospital of Sichuan University
Outcome results
None listed