Acute mountain sickness
Conditions
Interventions
Dexamethasone group:The subjects took dexamethasone acetate tablets daily at a dose of 1.5mg/time, twice a day, followed by monitoring of vital signs and testing of habituation levels at different tim
Staged oxygen weaning group:The initial oxygen concentration of the subjects was 4L/min, and vital signs including blood pressure, heart rate, respiration, and oxygen saturation were measured every ha
Combined group:On the basis of stepwise deoxygenation, the subjects took dexamethasone acetate tablets daily at a dose of 1.5mg/time, twice a day, until reaching initial habituation.
Control group:The subjects did not undergo any intervention and underwent vital sign monitoring and habituation level testing at different time points. Check vital signs every half hour, including blo
Sponsors
General Hospital of Xizang Military Command of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Participants enter high-altitude areas (above 3000 meters above sea level) from plain areas (below 500 meters above sea level) within one week; 2. Participants need to live, work, or engage in high-intensity physical activities in high-altitude environments and have a need for high-altitude adaptation; 3. No serious heart, lung, circulatory, or nervous system diseases; 4. Within the age range of 18-65 years old; 5. Participants need to understand the research purpose, process, and potential risks, be willing to participate in the research and practice of high-altitude ladder deoxygenation therapy, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Serious illness: The candidate suffers from severe heart, lung, or circulatory system diseases and cannot withstand the physiological challenges brought by high-altitude stepwise deoxygenation therapy; 2. Pregnant women or participants with severe psychological disorders; 3. Having traveled to or resided in the plateau for a long time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to achieve preliminary acclimatization;Safety outcomes (including adverse events, vital signs, and laboratory abnormalities); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of acute mountain sickness;Incidence rate of psychological disorders;Proportion of complete, basic, preliminary, and non-acclimatization;Proportion of severe altitude sickness;Proportion of recurrent altitude illness after acclimatization;Total oxygen consumption; | — |
Countries
China
Contacts
Public ContactWang Bowen
General Hospital of Xizang Military Command of the Chinese People's Liberation Army
Outcome results
None listed