Sleep disorders
Conditions
Interventions
Sleep disorder group:No
The group with good sleep quality:No
The treatment group for sleep disorders:Two days before the operation, the patients were given brain microstate monitoring before going to sleep every day. Then, dexmedetomidine (DEX) at a dose of 1.0
The placebo group of patients with sleep disorders:Two days before the operation, the patients in the saline placebo group were given brain microstate monitoring before going to bed every day. Then, n
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age ranging from 65 to 80 years old; 2. ASA classification level II-III; 3. Patients scheduled for general anesthesia, with the operation duration ranging from 1 hour to 6 hours; 4. Preoperative MMSE score is normal (illiterate>= 17 points, primary school education >=20 points, junior high school or above >= 24 points).
Exclusion criteria
Exclusion criteria: 1. Patients allergic to anesthetic drugs; 2. Those who have taken any sleep medication within 4 weeks prior to enrollment; 3. Patients with neurological disorders (such as stroke, Parkinson's disease, multiple sclerosis); 4. Patients with mental disorders (bipolar disorder, schizophrenia, Beck Depression Inventory (BDI) score > 20 or Beck Anxiety Inventory (BAI) score > 45); 5. Patients with sleep apnea syndrome or restless legs syndrome; 6. Pregnant patients; 7. Patients who refuse to participate in this experiment; 8. Patients with severe cognitive dysfunction, hearing or visual impairments; 9. Patients who are currently involved in other drug research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in perioperative electroencephalogram microstates in elderly patients with preoperative sleep disorders;The incidence of delirium within 7 days after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The perioperative a peak frequency of the patient;Dexmedetomidine combined with stellate ganglion blockage on the perioperative electroencephalogram microstates of patients; | — |
Countries
China
Contacts
Public ContactJiang Zhangjie
The First Affiliated Hospital of Nanchang University
Outcome results
None listed