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Placental multi-omics reveals the mechanism of abnormal trophoblast invasion in placental implantation

Placental multi-omics reveals the mechanism of abnormal trophoblast invasion in placental implantation

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122296
Enrollment
Unknown
Registered
2026-04-11
Start date
2026-04-11
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

placenta accreta spectrum disorders

Interventions

Placenta accreta group:none

Sponsors

Zhengzhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Meets the diagnostic criteria for placenta accreta; 2. Maternal age >= 18 years; 3. Gestational age >= 24 weeks; 4. Singleton pregnancy, natural conception, no obvious uterine contractions during prenatal period, and the pregnancy outcome was always cesarean section; 5. The pregnant woman has no history of drug abuse, smoking or drinking; 6. All patients with placenta accreta are cases of complete placenta previa; 7. Each patient was informed of the function of the placenta and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. History of primary chronic internal medicine diseases such as hypertension, diabetes, heart disease, kidney disease, systemic lupus erythematosus; 2. History of acute or chronic infectious diseases and pregnancy complications such as fetal chromosomal abnormalities or developmental deformities. 3. Exclude pregnancy complications such as premature rupture of membranes, excessive or insufficient amniotic fluid, or placental abruption; 4. Individuals conceived through assisted reproductive technology; 5. Twins and multiple fetuses; 6. Gestational age < 18 years old; 7. Fetal age < 24 weeks.

Design outcomes

Primary

MeasureTime frame
transcriptome;proteome;

Secondary

MeasureTime frame
Metabolome;

Countries

China

Contacts

Public ContactZhang Fang

Zhengzhou Central Hospital

yitianbian85@126.com+86 371 6769 0850

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026