Depression co-occurring with breast cancer
Conditions
Interventions
Depression co-occurring with breast cancer observation group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Female
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 20–75 years, female, with pathologically confirmed advanced breast cancer (TNM stage III/IV). 2.Meet the DSM-5 diagnostic criteria for depression (PHQ-9 = 10), and have not used antidepressants for = 4 weeks. 3.Estimated survival > 6 months, ECOG score = 2. 4.Without central nervous system metastasis. 5.Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.A history of non-depressive psychiatric disorders (such as schizophrenia, bipolar disorder) and severe suicidal tendency. 2.Abnormal liver and kidney function (ALT/AST > 3× ULN, Cr > 1.5× ULN). 3.Patients treated with tamoxifen (avoid interaction with SSRIs). 4.Allergy or contraindication to SSRI medications;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-Free Survival;Incidence of distant metastasis;Changes in EV-miR-20a-5p levels;Objective Response Rate (ORR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in depression score;Quality of life;Correlation analysis of EV-miR-20 levels with the progression and metastasis of breast cancer; | — |
Countries
China
Contacts
Public ContactYuan Minlan
West China Hospital of Sichuan University
Outcome results
None listed