Gynecological Laparoscopic Operation
Conditions
Interventions
BioZ-guided Group:Following induction of anesthesia, the BioZ non-invasive hemodynamic monitoring system (BioZ.com, CardioDynamics, San Diego, CA, USA) was continuously connected throughout the entire
Conventional Ventilation Group:Patients in this group were managed without the BioZ monitoring system. Following induction of anesthesia, the VCV mode was initially employed. After the establishment o
Sponsors
Anesthesiology Department of Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age: 18–65 years; 2.Body Mass Index (BMI): 24–35 kg/m^2; 3.ASA Physical Status: Class I–III; 4.Type of Surgery: Elective gynecological laparoscopic surgery (e.g., laparoscopic myomectomy, ovarian cystectomy, and total hysterectomy); 5.Estimated Duration of Pneumoperitoneum: >=60 minutes.
Exclusion criteria
Exclusion criteria: 1.Major Organ Dysfunction: Including severe cardiac insufficiency (NYHA Class III/IV), severe hepatic insufficiency (Child-Pugh Class C), and severe renal impairment (eGFR 9%) or uncontrolled hypertension (SBP > 180 mmHg). 5.Abdominal Conditions: Intra-abdominal hypertension (IAP > 12 mmHg), massive ascites, or a history of abdominal surgery likely to affect diaphragmatic movement. 6.Pre-existing Sleep Apnea: Preoperative moderate-to-severe obstructive sleep apnea (OSA, STOP-Bang score >= 5). 7.Surgical History: History of thoracic or upper abdominal surgery within the past 6 months. 8.Nutritional Status: Preoperative severe malnutrition (serum albumin = 4). 9.Others: Emergency surgery, pregnant or lactating women, known allergy to study medications, participation in other interventional clinical trials, or any condition deemed unsuitable by the investigator (e.g., communication barriers).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative pulmonary complications (PPCs) within the first 3 postoperative days.;The incidence of early postoperative diaphragmatic dysfunction (as assessed by ultrasound).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic Parameters;Respiratory Mechanics Indicators;Postoperative extubation time;Awakening time;Discharge time;hospital stays; | — |
Countries
China
Contacts
Public ContactJianjuan Ke
Zhongnan Hospital of Wuhan University
Outcome results
None listed