chronic kidney disease (CKD)
Conditions
Interventions
Usual Care Control Group:Routine Care and Health Education at Matching Frequency
Exercise Intervention Group:Structured Aerobic Exercise Intervention with Behavioral Maintenance Program
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years; 2. Being in a non-dialysis state and meeting the diagnostic criteria for CKD according to the KDIGO 2021 guidelines, i.e., eGFR < 60 mL/min/1.73 m² sustained for over 3 months, or presence of other markers indicative of kidney damage; and with 15 mL/min/1.73 m² < eGFR < 60 mL/min/1.73 m², corresponding to CKD stages 3-4; 3. Clinically stable, defined as having an eGFR fluctuation within 15% and a urinary albumin-to-creatinine ratio fluctuation within 20% during the 3 months prior to enrollment, with no history of acute exacerbation; 4. Possessing basic physical mobility, with a 6-minute walking distance exceeding 100 meters, and without severe motor dysfunction; 5. No history of regular high-intensity exercise in the preceding 3 months, i.e., cumulative moderate-intensity exercise of less than 60 minutes per week; 6. Voluntarily signing the informed consent form and committing to complete all follow-ups and assessments specified by the study protocol.
Exclusion criteria
Exclusion criteria: 1. Presence of severe and uncontrolled comorbid conditions, such as systolic blood pressure persistently =160 mmHg or diastolic blood pressure persistently =100 mmHg despite treatment with two or more antihypertensive agents; or uncontrolled diabetes with a glycated hemoglobin (HbA1c) level =9.0%; or severe hepatic insufficiency classified as Child-Pugh grade B or higher; 2. History of substance or alcohol dependence, defined as an alcohol intake of =140 grams per week; 3. Occurrence of a major cardiovascular event within the past 3 months, such as myocardial infarction, stroke, or hospitalization for heart failure; 4. Females who are pregnant or lactating; 5. Presence of unstable cardiovascular diseases, such as severe arrhythmia or frequent angina attacks; or other contraindications to exercise, such as acute infection or severe osteoporosis with high fracture risk; 6. Severe motor impairment due to conditions such as hemiplegia or amputation; 7. Cognitive or psychiatric disorders, such as dementia or schizophrenia, that preclude understanding of or cooperation with the study procedures; 8. Planned initiation of dialysis therapy or kidney transplantation within the next 6 months; 9. Current participation in another interventional clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| estimated Glomerular Filtration Rate (eGFR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise Capacity;Health-Related Quality of Life (HRQoL);Oxidative Stress Biomarkers;Inflammatory Biomarkers;Nutritional Status Assessment Parameters;Cardiovascular Structure and Function Parameters;CKD-MBD–related parameters;Blood Biochemical and Metabolic Parameters; | — |
Countries
China
Contacts
Public ContactTang Chun
The Seventh Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed