Coronary heart disease
Conditions
Interventions
The taVNS group:Transcutaneous auricular vagus nerve stimulation(taVNS)
The sham taVNS group:Pseudo-transcutaneous auricular vagus nerve stimulation
Sponsors
ShangHai ChangHai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18 - 80 years old; 2.ASA ?~III; 3.BMI 18.5~28; 4.Undergoing open heart valve surgery or coronary artery bypass grafting under the assistance of elective extracorporeal circulation; 5.Voluntary signing of the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Severe organ dysfunction (cerebral infarction, angina pectoris, severe heart failure, severe valve disease combined with heart failure, severe impairment of pulmonary function, liver and kidney dysfunction); 2.Severe mental or neurological disorders; 3.The skin of the stimulated area is severely damaged. 4.Preoperative consciousness disorder, inability to communicate or understand the test content, or inability to provide informed consent. 5.Merging neuromuscular diseases; 6.Has a history of drug abuse (including opioid drugs); 7.Received vagus nerve stimulation or acupuncture treatment within 1 month prior to enrollment; 8.Those who have implanted electronic devices such as cardiac pacemakers or automatic implantable cardioverter defibrillators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 Recovery Quality Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative resting and active pain (VAS) scores;Neutrophil/lymphocyte ratio (NLR);Ainsworth Insomnia Scale (AIS) score;Serum creatine kinase isoenzyme, troponin I;Postoperative mechanical ventilation duration;Systemic Immune Inflammation Index (SII);Quality of Recovery Scores of QoR-15;Delirium score;The incidence rates of death within 28 days after surgery, stroke, reoperation, and adverse events related to taVNS;The incidence of nausea and vomiting;The occurrence of adverse reactions related to electrical stimulation, such as ear pain, headache, dizziness, redness and swelling of the skin, or skin damage.;Blood test results: Liver and kidney function parameters (ALT, AST, creatinine, glomerular filtration rate); | — |
Countries
China
Contacts
Public ContactWang jiafeng
ShangHai ChangHai Hospital
Outcome results
None listed