Cirrhosis-related AKI
Conditions
Interventions
Model development cohort:NA
External prospective validation cohort:NA
External retrospective validation cohort:NA
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18 years, no gender restriction; 2.The clinical diagnosis meets the criteria for liver cirrhosis, which can be based on histology (pseudolobule formation confirmed by liver biopsy), imaging (ultrasound, CT, or MRI showing signs of cirrhosis); 3.Hospital stay = 48 hours, with complete clinical data at admission. 4. The cause of cirrhosis is not limited (including viral, alcoholic, autoimmune, cryptogenic, etc.), and there is no diagnosis of acute kidney injury before enrollment.
Exclusion criteria
Exclusion criteria: 1.Severe missing clinical data (missing rate > 20%); 2.Concomitant severe cardiopulmonary disease or primary hematologic disease; 3.Previous liver or kidney transplantation; 4.Concomitant hepatocellular carcinoma or tumors in other sites; 5.Previously diagnosed with chronic kidney disease or already requiring renal replacement therapy; 6.Recently used nephrotoxic drugs definitively; 7.Diagnosed with acute kidney injury (AKI) prior to admission, or AKI caused by other etiologies; 8.Age < 18 years; 9.Pregnant or lactating women; 10. Admission time < 48 hours; 11. Only one blood creatinine test value.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the receiver operating characteristic curve (AUC-ROC);Cirrhosis-associated acute kidney injury during hospitalization;Calibration curve;Decision curve analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory test data (blood routine test, liver and kidney function, electrolytes, blood glucose, blood lipids, coagulation function, etc.);Demographic indicators (gender, age, medical history, smoking and drinking history, etc.); | — |
Countries
China
Contacts
Public ContactXu Hexiang
Hefei First People's Hospital
Outcome results
None listed