Postoperative intestinal dysfunction
Conditions
Interventions
Dextrometomidine + Percutaneous Acupoint Electrical Stimulation Group:Intraoperative intravenous infusion of dexmedetomidine + percutaneous acupoint electrical stimulation (Zusanli, Shangjuxu, and San
Dextromethorphan + sham electroacupuncture stimulation group:Intraoperative intravenous infusion of dexmedetomidine + percutaneous acupoint sham stimulation (Zusanli, Shangjuxu, and Sanyinjiao)
Sponsors
Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>18 years; 2. Intended to undergo laparoscopic colon surgery under general anesthesia; 3. ASA classification (American Society of Anesthesiologists classification) grade I-III; 4. Consented to participate in the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Presence of sick sinus syndrome, severe sinus bradycardia (heart rate =III; 3. Allergy to dexmedetomidine; 4. Preoperative gastrointestinal dysfunction; 5. Body mass index (BMI)>30 kg/m^2; 6. Severe hepatic dysfunction (Child-Pugh C class); severe renal dysfunction (preoperative dialysis); ASA classification >=IV; 7. Planned creation of a new stoma or surgery for low rectal cancer; 8. Pregnancy or lactation; 9. Other circumstances deemed unsuitable for study participation by investigators or attending physicians; 10. Participation in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of bowel function recovery within 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus;Incidence of prolonged postoperative ileus;Incidence of postoperative nausea and vomiting;Pain scores on postoperative days 1–5;Sleep scores on postoperative days 1–5;Incidence of delirium on postoperative days 1–5;Postoperative length of hospital stay;30-day postoperative complication rate;30-day readmission rate;90-day mortality;Quality of recovery on postoperative day 1;Adverse events during recovery from anesthesia in the PACU;Postoperative 24-hour opioid consumption (with non-opioid analgesics converted to opioid-equivalent doses);30-day mortality;Association analysis of survival time; | — |
Countries
China
Contacts
Public ContactGu Xiaoping
Nanjing Drum Tower Hospital
Outcome results
None listed