colorectal cancer
Conditions
Interventions
OS(Oliceridine + Sufentanil):Oliceridine 0.35 mg/kg + Sufentanil 1 µg/kg, patient-controlled intravenous analgesia (PCIA) for 48 hours postoperatively. Background infusion 2 mL/h, bolus 0.5 mL, lockou
OE(Oliceridine + Esketamine):Oliceridine 0.35 mg/kg + Esketamine 1 mg/kg in 100 mL saline. PCIA: background 2 mL/h, bolus 0.5 mL, lockout 15 min. Each bolus: oliceridine 1.75 µg/kg + esketamine 5 µg/k
Sponsors
Henan University Huaihe Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 65 to 80 years. 2. Scheduled surgery: Elective laparoscopic radical resection of colorectal cancer. 3. Body mass index (BMI): 18.5 to 30.0 kg/m2. 4. Voluntary participation: Ability to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of drug allergies; 2. Severe liver or kidney dysfunction; 3. History of chronic pain or long-term use of opioid drugs; 4. Severe mental or cognitive disorders; 5. History of substance or alcohol abuse; 6. Conversion to open surgery during operation or occurrence of serious complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative active pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total consumption of oliceridine within 48 hours post-operation;Postoperative adverse reaction incidence rate;Postoperative Recovery Quality Score;Number of compressions of analgesic pump;First anal exhaust time after surgery;Post hospitalization duration; | — |
Countries
China
Contacts
Public ContactLiang Limin
Henan University Huaihe Hospital
Outcome results
None listed