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A prospective study on immediate mild hypothermia therapy after endovascular recanalization for acute cerebral infarction due to large vessel occlusion in the posterior circulation to reduce adverse outcomes

A series of studies on the prediction and intervention of poor outcomes in acute ischemic stroke caused by large vessel occlusion: A prospective study on reducing poor outcomes through post-interventional craniocerebral mild hypothermia treatment in acute ischemic stroke of the posterior circulation due to large vessel occlusion

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122209
Enrollment
Unknown
Registered
2026-04-10
Start date
2026-04-15
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute cerebral infarction

Interventions

Head mild hypothermia group:Apply mild hypothermia to the head immediately after surgery
Control group:Routine treatment

Sponsors

Heyuan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Patients with acute cerebral infarction due to large vessel occlusion in the posterior circulation receiving endovascular recanalization therapy, with occlusion sites including the V1 segment of the vertebral artery, the V4 segment of the vertebral artery, the basilar artery, or tandem lesions in the posterior circulation; (2) Onset time = 24 hours; (3) NIHSS score at onset = 6; (4) ASPECTS score at onset = 6; (5) Medically stable condition; (6) Informed consent signed by the patient's family members to participate in this study.

Exclusion criteria

Exclusion criteria: (1) Anterior circulation large vessel occlusion, including the M1 segment of the middle cerebral artery, the M2 segment of the middle cerebral artery, the extracranial segment of the internal carotid artery, the intracranial segment of the internal carotid artery, the anterior cerebral artery, or tandem lesions in the anterior circulation; (2) Failed endovascular recanalization; (3) Incomplete follow-up data.

Design outcomes

Primary

MeasureTime frame
mRS score on the 90th day after operation;Death;Cerebral hernia;—

Countries

China

Contacts

Public ContactWensheng Zhang

Heyuan People's Hospital

494172988@qq.com+86 188 2640 1949

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026