Asthma, chronic obstructive pulmonary disease (COPD) and respiratory infections
Conditions
Interventions
Observation group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.GBD: Include burden data such as incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for asthma, COPD, and lower respiratory infections (LRI) from GBD 2021 or the latest version. 2.ELSA: Participants aged >=50 years from ELSA Waves 1-10 with complete baseline socioeconomic, health behavior, clinical measurement, and disease history data. 3.Genetic data: Summary statistics from public GWAS catalogs or platforms such as IEU OpenGWAS, covering asthma, COPD, lung function (FEV1/FVC), infection susceptibility, etc.
Exclusion criteria
Exclusion criteria: 1.GBD: Non-core respiratory disease burden data. 2.ELSA: Individuals with missing rates >20% for key variables; individuals lost to follow-up at baseline or with severely inconsistent data. 3.Genetic data: GWAS studies with severe sample overlap, poorly controlled population stratification, or low quality scores.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age-standardized incidence;Geographic Variation in Disease Burden;Time Trend of Disease Burden;Age-standardized DALYs Rate;Association Strength between Genetic Risk Score and Disease Risk;Association between Smoking and Disease Burden;Age-standardized Prevalence Rate;Age-standardized Mortality Rate;Association between Socioeconomic Status and Disease Burden; | — |
Secondary
| Measure | Time frame |
|---|---|
| Burden of Respiratory Disease Comorbidity;Interaction between Genetic Susceptibility and Socioeconomic Factors on Disease Risk;Healthcare Utilization (Hospitalization Rate);Subgroup Differences in Disease Burden by Sex and Age; | — |
Countries
China
Contacts
Public ContactShuanshuan Xie
Shanghai Tenth People's Hospital
Outcome results
None listed