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Functional validation of DNAH7 gene mutation in recurrent abdominal Henoch-Schönlein purpura in children

Functional validation of DNAH7 gene mutation in recurrent abdominal allergic purpura in children

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122188
Enrollment
Unknown
Registered
2026-04-10
Start date
2026-04-23
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Henoch-Schönlein purpura

Interventions

Case group:None
Control group:None

Sponsors

Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Case: One child with recurrent abdominal HSP who tested positive for DNAH7 mutation (2) Control: Four children who presented with recurrent abdominal pain and were diagnosed with functional abdominal pain or non-recurrent abdominal allergic purpura (matched by gender and age with the case).

Exclusion criteria

Exclusion criteria: History of other autoimmune diseases or vasculitis.

Design outcomes

Primary

MeasureTime frame
Ultrastructural index of cilia;Tissue expression index of DNAH7 protein (immunohistochemistry);—

Secondary

MeasureTime frame
Expression level of DNAH7 protein (Western Blot);Inflammatory factor levels (ELISA);—

Countries

China

Contacts

Public ContactWenyan Huang

Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University

hwy65@hotmail.com+86 189 6402 5491

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026