Postoperative delirium
Conditions
Interventions
The group that received nasal administration of dexmedetomidine:30 minutes before the operation, the patient was given a nasal spray of dexmedetomidine at a dose of 1 microgram per kilogram while in a
The group receiving intravenous infusion of dexmedetomidine:10-15 minutes before anesthesia induction, 1.0 µg/kg of dexmedetomidine was intravenously infused. The maintenance dose during general anest
Control group:Give equal volume normal saline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age >=65 years old (2) ASA classification I–III (3) Scheduled for elective lumbar fusion surgery (4) Signed informed consent form (5) BMI 18.5 - 29.9 kg/m^²
Exclusion criteria
Exclusion criteria: (1) Refusal to sign the consent form; (2) Mini-Mental State Examination (MMSE) score [illiterate = 2mg/dl, etc.); (8) Severe renal insufficiency (increase in serum creatinine by 0.5mg/dl, or increase by 50%, or serum creatinine > 2mg/dl, glomerular filtration rate < 60ml/(min·1.73m^2)-1, etc.); (9) Allergy and contraindication to dexmedetomidine drug; (10) Severe pulmonary dysfunction (FEV1% < 50%, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium score;The incidence of nasal mucosa injury;Time from drug discontinuation to tube removal;The usage of vasoactive drugs;QoR-15 score;The usage of postoperative analgesic drugs;Intraoperative hemodynamic indicators;The time of the first postoperative ambulation after discharge;Postoperation pain; | — |
Countries
China
Contacts
Public ContactWang GuangLei
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed