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Early Warning for Unplanned Discontinuation of CRRT in Patients with Sepsis-Induced Coagulopathy Based on Thrombus Formation Trends and Rate Curves in the Extracorporeal Circuit

Early Warning for Unplanned Discontinuation of CRRT in Patients with Sepsis-Induced Coagulopathy Based on Thrombus Formation Trends and Rate Curves in the Extracorporeal Circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122174
Enrollment
Unknown
Registered
2026-04-09
Start date
2024-12-26
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Case Group:None
Control Group:None

Sponsors

Qingdao Municipal Hospital??
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion Criteria for the SIC Patient Case Group:?? 1. Age >= 18 years; 2. Underwent CRRT for a duration of >= 12 hours; 3. Received blood purification therapy using the Jafron DX-10 system with its matching tubing set and the Fresenius AV1000s filter; 4. Normal function of the blood purification circuit (able to aspirate 20 ml of blood from both lumens within 6 seconds); 5. Experienced unplanned discontinuation of therapy (i.e., total CRRT treatment time = 24 hours) during their CRRT treatment.

Exclusion criteria

Exclusion criteria: ?Exclusion Criteria:?? 1. Patients who were discharged automatically (against medical advice) or died during the treatment; 2.Treatment termination due to non-extracorporeal circuit coagulation reasons, such as patient resuscitation or equipment failure; 3.Patients undergoing hemoperfusion, plasma exchange, artificial liver blood purification, or various combined therapies. ??The exclusion criteria for the control group were the same as those for the case group.??

Design outcomes

Primary

MeasureTime frame
Coagulation Status Pre-filter Pressure;Pre-filter Pressure;Duration of continuous renal replacement therapy;

Secondary

MeasureTime frame
Activated partial thromboplastin time;Red blood cell count;Age;

Countries

China

Contacts

Public ContactChenchen Jing

Qingdao Municipal Hospital??

1073532536@qq.com+86 178 6565 1683

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026