Major Depressive Disorder (MDD)
Conditions
Interventions
Low Suicide Risk Depression Group:no
High Suicide Risk Depression Group:no
Healthy Control Group:no
Sponsors
Hefei Fourth Peoples Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Major Depression High Suicide Risk Group: (1) Meets DSM-5 diagnostic criteria for depression and is independently diagnosed by two psychiatrists of associate senior level or above, reaching a consensus. (2) Assessed as high risk using the Suicide Ideation Scale (SSI), defined as an SSI total score =6 or the presence of clear suicidal thoughts, plans, or behaviors. (3) Aged 18-60, of Han ethnicity, any gender. (4) At least junior high school education, able to understand the study content and communicate effectively. (5) Voluntarily participate and sign written informed consent. 2. Major Depression Low Suicide Risk Group: Inclusion criteria are basically the same as the high-risk group, with the core difference being risk assessment: SSI total score <6, and no clear suicidal thoughts, plans, or behaviors. 3. Healthy Control Group: (1) Matched with the case groups in terms of age, gender, and education level. (2) At least junior high school education, normal audiovisual ability. (3) Confirmed to have no current or past history of any mental disorder through standardized mental examinations and diagnostic interviews. (4) Voluntarily participate and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the patient group: (1) Suffering from severe uncontrolled physical diseases (such as cardiovascular, respiratory, or organic neurological diseases) that may affect speech or cognitive function. (2) History of dependence on or abuse of psychoactive substances, or any use within three months prior to enrollment. (3) Presence of severe impulsive behavior or currently in a high-risk suicidal state requiring urgent intervention. (4) Received modified electroconvulsive therapy (MECT) within one month before enrollment. (5) Currently taking medications that may significantly affect language function (such as high-dose sedatives or anticholinergic drugs). (6) Comorbid other psychiatric disorder diagnoses (such as schizophrenia, bipolar disorder, etc.). (7) Presence of severe speech or hearing impairment. 2. Exclusion criteria for the healthy control group: (1) Current or past history of any psychiatric disorder, or a family history of psychiatric disorders in first- or second-degree relatives. (2) Presence of hearing, speech expression disorders, or diseases of the articulatory organs. (3) Currently taking medications that affect mental state or speech expression. (4) Experienced major life stressors or traumatic events within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis and Severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical phenotype; | — |
Countries
China
Contacts
Public ContactLiling Gao
Hefei Fourth Peoples Hospital
Outcome results
None listed