Depressive episode of mood disorder with suicidal ideation
Conditions
Interventions
Depressive Episode Group1:Modified Electroconvulsive Therapy(MECT)
Depressive Episode Group2:Individualized and Precision Modified Electroconvulsive Therapy
Sponsors
Beijing An Ding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the patient group (all of the following 5 conditions must be met): (1) Outpatient or inpatient, aged 18–65 years (including 18 and 65), any gender, right-handed; (2) Current episode meets the diagnostic criteria for major depressive disorder, bipolar I or II disorder with depressive episodes according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); (3) BSI-CV item 4 or item 5 score > 0; (4) Education level above primary school, able to understand the scale content; (5) Patient has signed the informed consent form. 2. Inclusion criteria for healthy controls: Inclusion criteria: (1) Aged 18–65 years (including 18 and 65), any gender, right-handed, education above primary school; (2) Matched with the patient group in terms of gender, age, handedness, and education; (3) HAMD-17 score =7; (4) Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the patient group (meeting any one condition is sufficient for exclusion): (1) Current or past diagnosis of neurodevelopmental disorders, neurocognitive disorders, schizophrenia spectrum and other psychotic disorders, substance-related and addictive disorders according to DSM-5; (2) Presence of significant psychotic symptoms (delusions, hallucinations); (3) Currently having severe or unstable central nervous system, cardiovascular, respiratory, liver, kidney, endocrine, hematologic, or other systemic diseases, and the researcher considers not suitable for this study; (4) Researchers judge a potential risk of drug abuse and addiction; (5) Currently taking medications containing reserpine; (6) Presence of general anesthesia risk factors; (7) History of seizures (children’s simple febrile seizures without sequelae do not require exclusion); (8) Previously ineffective MECT or severe adverse reactions; underwent MECT within the past 3 months; (9) Participated in other clinical trials within the past 3 months; (10) Female subjects who are pregnant, breastfeeding, or planning pregnancy, or male subjects with plans to conceive during the study; (11) Researchers consider the subject unsuitable for participation in this study. 2. Exclusion criteria for healthy controls: (1) Presence of metal implants or dental prostheses, pregnancy, breastfeeding, claustrophobia, or other MRI contraindications; (2) Major somatic diseases; (3) History of mental disorders meeting diagnostic criteria or family history of mental disorders; (4) Left-handed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suicide remission rate after MECT treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The recovery rate and effective rate at the end of the study;Resting-state EEG data;Magnetic resonance imaging indicators;The changes in the scores of each clinical symptom scale at each research time point compared to the baseline;The changes in the quality of life scale scores at each research time point compared to the baseline;adverse reaction; | — |
Countries
China
Contacts
Public ContactWang xue
Beijing An Ding Hospital, Capital Medical University
Outcome results
None listed