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The Value of the ROX Index in Assessing the Efficacy of Non-Invasive Ventilation/HFNC in Pediatric Patients with Lower Respiratory Tract Infections

The Early Predictive Value of the ROX Index for Initiating and Escalating Oxygen Therapy in Infants and Young Children with Lower Respiratory Tract Infections

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122144
Enrollment
Unknown
Registered
2026-04-09
Start date
2026-04-10
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower respiratory tract infection

Interventions

According to the non-invasive/HFNC treatment results of the patient, they are divided into a treatment success group and a treatment failure group:None

Sponsors

Kunming Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 3 Years

Inclusion criteria

Inclusion criteria: 1. Age <= 36 months; 2. Diagnosed with acute lower respiratory tract infection; 3. Pediatric patients receiving non-invasive ventilation/high-flow nasal cannula therapy during hospitalization.

Exclusion criteria

Exclusion criteria: 1. Patients with severe congenital heart disease, neuromuscular disorders, severe metabolic acidosis, severe immunodeficiency, or significant chest wall deformities; 2. Patients with chronic respiratory failure requiring long-term home oxygen therapy; 3. Neonates; 4. Patients who received invasive ventilation prior to admission or require immediate tracheal intubation upon admission; 5. Pediatric patients requiring escalation of respiratory support measures within 48 hours.

Design outcomes

Primary

MeasureTime frame
HFNC Treatment Success Rate;Survival rate;Non-invasive ventilation Treatment Success Rate;ROC curve;

Secondary

MeasureTime frame
Arterial Blood Gas Analysis;

Countries

China

Contacts

Public ContactFu Hongmin

Kunming Children's Hospital

Fuhongmin@kmmu.edu.cn+86 151 9891 0315

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026