Knee osteoarthritis (KOA)
Conditions
Interventions
HA+CS:Hyaluronic acid + corticosteroid knee cavity injection
HA+PRP:Hyaluronic acid + platelet-rich plasma knee joint injection
Sponsors
Songyang County Hospital of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Adults aged 40–75 years; 2.The main diagnosis is unilateral idiopathic knee osteoarthritis. 3.The diagnosis must be confirmed as Kellgren-Lawrence level II or level III by X-ray examination on X-rays of the standing before and after and the side knee joint. 4.Participants must report persistent knee joint symptoms, which are defined as pain for most days (=4 days) for at least one week in the first 3 months. 5.The baseline WOMAC pain sub-scale score =5 (0-20 scale) to ensure that there is enough symptom load to detect improvement.
Exclusion criteria
Exclusion criteria: 1.Inflammatory joint diseases (such as rheumatoid arthritis); 2.Secondary osteoarthritis (for example, caused by major trauma); 3.Symptomatic osteoarthritis of other lower limb joints that may be confused with functional evaluation; 4.History of knee joint surgery or joint replacement surgery on the affected side; 5.Inject drugs into the affected knee joint within the first 6 months; 6.Severe obesity (body mass index, BMI>35kg/square metre); 7.Patients associated with coagulation disorders, active infection, immunosuppression and patients who cannot provide consent tests; 8.Other patients who are not suitable for this study; 9. Currently participating in any other interventional clinical trial. 10. Any other condition that may compromise the safety of the subjects or the integrity of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Continuous variables (0-20 points, high score = pain); | — |
Secondary
| Measure | Time frame |
|---|---|
| Continuous variables (0-100mm, high score = pain);Continuous variables (milliseconds, ms);Continuous variables (0-68 points, high score = disfunction heavy);Continuous variables (0-100 points, high score = good function);Continuous variables (number of times, high score = good function);Classified variables (existed/did not occur); | — |
Countries
China
Contacts
Public ContactQUE QIHONG
Songyang County Hospital of traditional Chinese Medicine
Outcome results
None listed