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Exploration of the Neural Perception Difference Mechanism Between Subjective and Objective Refraction Based on Multimodal Imaging and Neurovisual Features

Exploration of the Neural Perception Difference Mechanism Between Subjective and Objective Refraction Based on Multimodal Imaging and Neurovisual Features

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122125
Enrollment
Unknown
Registered
2026-04-09
Start date
2026-04-30
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia, astigmatism

Interventions

Observation group:None

Sponsors

Hangzhou MSK Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18–45 years, both genders, myopia ranging from -0.50D to -10.00D, astigmatism = 1.0; 2.No organic ocular diseases (e.g., cataract, glaucoma, retinopathy, keratopathy), no history of ocular surgery or trauma; 3.No systemic diseases (e.g., diabetes, hypertension, neurological disorders), no mental illness or cognitive impairment, able to cooperate with all examinations and assessments; 4.No use of medications affecting refractive status (e.g., atropine eye drops) and no orthokeratology lens wear within the past 3 months.

Exclusion criteria

Exclusion criteria: 1.Failure to meet the inclusion criteria; 2.Inability to cooperate with subjective refraction, multimodal imaging, or other procedures during the examination; 3.Imaging data of insufficient quality (e.g., motion artifacts, inadequate resolution) preventing extraction of valid 126-dimensional radiomic features using the AIIO intelligent diagnostic program; 4.Loss to follow-up or withdrawal from the study.

Design outcomes

Primary

MeasureTime frame
Difference between subjective refraction and objective refraction (subjective refraction minus objective refraction);Retinal nerve fiber layer (RNFL) thickness (average and quadrant-specific);Corneal aberration parameters (higher-order aberrations, lower-order aberrations);126-dimensional radiomic features;

Secondary

MeasureTime frame
Long-term refraction of daily life;Fundus image;Fovea image from OCT;

Countries

China

Contacts

Public ContactZhang Jun

Hangzhou MSK Eye Hospital

mskzj@sina.cn+86 186 6704 6602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026