Clinical study of tigelilidine for patient-controlled intravenous analgesia combined with adductor canal block after knee arthroplasty

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122108

Enrollment

Unknown

Registered

2026-04-09

Start date

2026-04-20

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia after knee arthroplasty

Interventions

Group S:Group S: sufentanil 2ug/kg+ dolasetron 0.4mg, diluted to 100ml of normal saline

Group T:Group T: tegilidine fumarate 0.2mg/kg+ dolasetron 0.4mg, diluted to 100ml of normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Patients of both sexes, aged 18-64 yr, of American Society of Anesthesiologists physical status?-?, undergoing total knee arthroplasty under spinal anesthesia, were selected.

Exclusion criteria

Exclusion criteria: 1.Allergy or contraindications to the planned anesthetic drugs; 2.Severe dysfunction of vital organs; 3.The patient had chronic pain before surgery and received long-term opioid treatment; 4.Long-term use of psychotropic drugs or cognitive impairment unable to cooperate with the study; 5.Refusal to participate in this study.

Design outcomes

Primary

Measure	Time frame
15-item Quality of Recovery score;	—

Secondary

Measure	Time frame
15-item Quality of Recovery score;Visual Analog Scale Score;Consumption of analgesics(PO48);Rescue analgesia;Postoperative satisfaction score;Postoperative adverse events;	—

Countries

China

Contacts

Public ContactWang Weilian

Jingzhou Hospital Affiliated to Yangtze University

wangweilian27@163.com+86 181 0716 8494

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026