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Effect of preoperative hypertonic saline infusion on delayed neurocognitive recovery in elderly patients with hip fracture

Research on hypertonic saline solution alleviating postoperative cognitive dysfunction by promoting microglial M2 polarization

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122105
Enrollment
Unknown
Registered
2026-04-09
Start date
2026-05-10
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

Experimental group:Preoperative hypertonic saline infusion
Control group:Preoperative normal saline infusion

Sponsors

Chongqing Traditional Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged over 65 years and under 90 years with fragility hip fractures (femoral neck, femoral head, intertrochanteric, or subtrochanteric fractures) scheduled for elective surgery; 2. American Society of Anesthesiologists (ASA) classification I to III; 3. Preoperative Montreal Cognitive Assessment (MoCA) score greater than 26.

Exclusion criteria

Exclusion criteria: 1. Patients with chronic fractures, multiple trauma, or pathological fractures; 2. Patients with severe primary or secondary diseases, such as severe hepatorenal or hematopoietic system disorders, severe cardiopulmonary dysfunction, or infectious diseases; 3. Patients with a definite history of neurological or psychiatric diseases or a history of taking corresponding medications before surgery; 4. Patients with addiction to drugs, alcohol, or other substances; 5. Patients with inflammation or a history of taking anti-inflammatory medications; 6. Patients with preoperative electrolyte imbalance; 7. Patients with preoperative coagulation dysfunction; 8. Patients allergic to HSH; 9. Patients with communication difficulties, such as severe hearing or visual impairment; 10. Patients who refuse to participate or are participating in another randomized clinical trial.

Design outcomes

Primary

MeasureTime frame
Incidence of delayed neurocognitive recovery;—

Secondary

MeasureTime frame
Unplanned ICU admission rate;Length of stay, cost of stay;Incidence of postoperative complications;Postoperative mortality;AChE level in peripheral blood;BChE level in peripheral blood;TNF-a level in peripheral blood;IL-1ß level in peripheral blood;IL-6 level in peripheral blood;—

Countries

China

Contacts

Public ContactZhou hongyan

Chongqing Traditional Chinese Medicine Hospital

1308354987@qq.com+86 191 2202 7628

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026