Coronary atherosclerotic heart disease
Conditions
Interventions
Gold Standard:Definition of Vulnerable Plaque by IVUS: A plaque is defined as high-risk/vulnerable if it meets at least one of the following criteria:
Plaque burden > 70%.
Minimum lumen area (MLA) < 4
Index test:Using deep learning algorithms or automated machine recognition to extract features of the retinal microcirculation from fundus images and fundus OCAT scans
Sponsors
The 7th People's Hospital of Zhengzhou
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years old, gender is not limited. 2. Selective coronary angiography (CAG) is planned due to clinical indications (e.g. stable angina, unstable angina, etc.). 3. CAG results show critical lesions (50%-70% lumen diameter stenosis) in at least one major coronary artery, and the clinician believes that IVUS is necessary or can be considered to guide therapeutic decisions. 4. The patient has a clear refractive interstitium and is able to cooperate in completing a high-quality fundus photography examination. 5. Patients understood the purpose and procedure of the study, participated voluntarily and signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients requiring urgent direct PCI such as acute ST-segment elevation myocardial infarction (STEMI). 2. Known history of severe allergy to contrast media or other contraindications to IVUS operation (e.g., severe renal insufficiency). 3. The target lesion is located in a severely tortuous, calcified vessel or in an in-stent restenotic lesion that is not expected to pass through the IVUS catheter. 4. Previous history of coronary artery bypass grafting (CABG). 5. Ocular disease that severely affects the morphology of the vasculature in the fundus, such as advanced glaucoma, retinal detachment, uveitis, and proliferative diabetic retinopathy. 6. Poor image quality in any modality (CAG, IVUS or fundus photographs) for subsequent quantitative analysis. 7. Pregnant or lactating women. 8. Other conditions that the investigator considers unsuitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC(Area Under the ROC Curve); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive predictive value, PPV;Negative predictive value, NPV; | — |
Countries
China
Contacts
Public ContactLei Yin
The 7th People's Hospital of Zhengzhou
Outcome results
None listed