Pharmacology
Conditions
Interventions
Sedation regimen of dexmedetomidine nasal spray+oral midazolam for pediatric patients:None
Dexmedetomidine nasal spray+oral chloral hydrate sedation regimen for pediatric patients:None
Pediatric patients receiving nasal spray of dexmedetomidine:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 4 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing procedural sedation in our hospital. 2. The legal guardians of the children voluntarily participated and signed the informed consent form. 3. Age of the children ranged from 1 to 4 years. 4. ASA physical status I–II.
Exclusion criteria
Exclusion criteria: 1. Children with known hypersensitivity to midazolam, dexmedetomidine, chloral hydrate, or any other study medications. 2. Children unable to take oral medications due to underlying disease. 3. Children with long-term use of drugs that may affect electroencephalography, including benzodiazepines, opioids, ketamine, and antiepileptic drugs. 4. Children with intellectual or cognitive impairment, neurological diseases, and those unable to complete the relevant assessments (epilepsy, brain injury, cerebral malacia, cerebral necrosis, mental retardation, various syndromes associated with developmental disorders). 5. Children with known abnormal electroencephalogram.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute and relative spectral power of EEG bands; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ratios of EEG frequency bands; | — |
Countries
China
Contacts
Public ContactXu Ying
Children's Hospital of Chongqing Medical University
Outcome results
None listed