Stroke
Conditions
Interventions
Broca Stimulation Group:Conventional language training + active iTBS over left Broca’s area + sham iTBS over left DLPFC
DLPFC Stimulation Group:Conventional language training + sham iTBS over left Broca’s area + active iTBS over left DLPFC
Combined Stimulation Group:Conventional language training + active iTBS over left Broca’s area + active iTBS over left DLPFC
Sponsors
Guangdong Provincial Second Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for ischemic or hemorrhagic stroke, first onset, disease duration of 1–12 months; 2.Aged 18–70 years, regardless of gender; 3.Right-handed, with stroke lesions located in the left cerebral hemisphere; 4.Meet the diagnostic criteria for aphasia; 5.Normal language function prior to onset, native language not restricted, educational attainment of primary school or above (>=6 years of education); 6.Able to maintain a sitting position in a wheelchair for more than 40 minutes; 7.The patient and their family understand the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Aphasia caused by other diseases such as brain tumor, Parkinson’s syndrome, motor neuron disease, traumatic brain injury, etc.; 2.Complicated with severe cognitive impairment, dysarthria, or apraxia of speech; 3.Complicated with hearing impairment or visual impairment, unable to complete assessment and training; 4.Contraindications to transcranial magnetic stimulation, such as cardiac pacemaker, cochlear implant, intracranial metallic implants, etc.; 5.Skin damage or allergy on the head and face, or those who underwent decompressive craniectomy, ventriculoperitoneal shunt and other conditions unsuitable for near-infrared brain function detection; 6.History of epilepsy or high risk of epileptic seizures; 7.Severe depression, anxiety, or diagnosis of other mental disorders; 8.Pregnant women or women of childbearing age planning pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Picture naming accuracy and mean reaction time;Western Aphasia Battery–Revised Chinese Version (WAB-R) AQ score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional near-infrared spectroscopy (fNIRS);Trail Making Test (AMT-A);Working memory; | — |
Countries
China
Contacts
Public ContactLi Jin
Guangdong Provincial Second Hospital of Traditional Chinese Medicine
Outcome results
None listed