Ocular surface diseases, including pterygium, corneal ulcer, and ocular surface burns.
Conditions
Interventions
Hydrogel Adhesion Group:Adhering ocular surface tissue with hydrogel.
Sponsors
Eye Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients for whom surgical adhesion of ocular surface tissue is indicated due to conditions such as pterygium, corneal ulcer, ocular surface burn, or pseudopterygium, involving procedures like conjunctival flap adhesion, amniotic membrane transplantation, or keratoplasty. 2. Aged 18–85 years (any gender) at the time of consent. 3. Ability to provide written informed consent for voluntary participation in the study. 4. Absence of severe systemic organic diseases, including but not limited to severe cardiac, hepatic, renal disorders, and malignant tumors.
Exclusion criteria
Exclusion criteria: 1. Patients with a known allergy or hypersensitivity to any component of the sutureless ophthalmic hydrogel (e.g., decellularized porcine corneal stroma, gelatin methacryloyl) or to any peri-/post-operative medication prescribed (e.g., anesthetics, antibiotics, steroids). 2. Patients with active systemic infection (e.g., bacterial, fungal, or viral infections such as HBV or HCV positivity). 3. Diabetic patients with poor glycemic control (HbA1c > 8.0%). 4. Pregnant or lactating women, women of childbearing potential not using adequate contraception, or women planning to become pregnant during the study period. 5. Patients who have participated in any other clinical trial or investigational study within one month prior to the screening visit. 6. Patients deemed by the investigator to be unsuitable for participation in this clinical study due to other comorbidities or reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular Irritation Score;Conjunctival Redness Score;IOP(mmHg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Condition of Conjunctival Flap Adhesion;Vision; | — |
Countries
China
Contacts
Public ContactWeiyun Shi
Eye Hospital of Shandong First Medical University
Outcome results
None listed