None
Conditions
Interventions
Observation group:None
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
2 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1.Age 2 to 8 years at the time of inclusion; 2.Diagnosis of Autism Spectrum Disorder (ASD) according to DSM-5 or equivalent clinical diagnosis, with moderate to severe severity (e.g., baseline CARS >= 30 or clinical assessment); 3.Previously received at least one session of low-concentration sevoflurane treatment at our center, with adequate medical records documenting treatment dates, dose/concentration and duration; 4.Availability of at least one of the following at both baseline (T0) and early follow-up (T1, preferably 7–30 days post-treatment): Children’s Eating Behavior Questionnaire (CEBQ) or a 3-day dietary record, and bowel habit records/notes; 5.Parental/guardian consent for retrospective analysis of de-identified records as required by the institutional IRB.
Exclusion criteria
Exclusion criteria: 1.Presence of significant somatic disease that may directly affect feeding or gastrointestinal function (e.g., congenital GI malformations, active inflammatory bowel disease, progressive metabolic disorders); 2.Major infection, surgery, or other acute events within 30 days before T0 or during the treatment period that could substantially alter laboratory or clinical outcomes; 3.Prior fecal microbiota transplantation (FMT) or ongoing long-term probiotic/prebiotic therapy within 30 days if such interventions would confound results and cannot be adequately adjusted for; 4.Insufficient medical records preventing retrieval of key outcome data (missing both T0 and T1 eating or bowel records and lacking any laboratory data); 5.Severe neurological comorbidity (e.g., uncontrolled generalized epilepsy) or other conditions judged by clinicians to preclude inclusion in the retrospective analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Children’s Eating Behavior Questionnaire (CEBQ) — Food Selectivity subscale score;Wexner constipation severity score;Autism Behavior Checklist (ABC) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Childhood Autism Rating Scale (CARS) score;Complete Blood Count;Stool routine;Blood biochemistry; | — |
Countries
China
Contacts
Public ContactTian Hang
Guangzhou Women and Children's Medical Center
Outcome results
None listed