Upper gastrointestinal diseases requiring painless gastroscopy
Conditions
Interventions
young and middle-aged male (18–64 years) :Combined with nalbuphine 0.1 mg/kg, sequential sedation with ciprofol
young and middle-aged female (18–64 years):Combined with nalbuphine 0.1 mg/kg, sequential sedation with ciprofol
elderly male (65–85 years):Combined with nalbuphine 0.1 mg/kg, sequential sedation with ciprofol
elderly female (65–85 years):Combined with nalbuphine 0.1 mg/kg, sequential sedation with ciprofol
Sponsors
The First Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 85 years, of any sex, with a body mass index (BMI) of 18–30 kg/m²; 2. Classified as American Society of Anesthesiologists (ASA) physical status I or II; 3. Scheduled to undergo painless gastroscopy; 4. Fully informed of the study details, willing to participate voluntarily, and able to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known allergy or contraindication to any drug involved in this study; 2. History of sedative or anesthetic abuse; 3. Contraindication to endoscopic procedures or refusal to receive anesthesia; 4. Anticipated difficult airway management, such as limited mouth opening or a modified Mallampati class IV; 5. History of severe hepatic, renal, psychiatric, cardiovascular, or neuromuscular disease; 6. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective dose (ED50) of ciprofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality and Efficiency of Sedation;Respiratory safety (incidence of hypoxemia and respiratory depression);Hemodynamic stability (incidence of hypotension, incidence of bradycardia, and use of vasoactive agents);Recovery experience and satisfaction (incidence of postoperative adverse events, patient satisfaction, endoscopist satisfaction);Patient vital signs at corresponding time points (SBP, DBP, MAP, HR, SPO2); | — |
Countries
China
Contacts
Public ContactZeng Zhaodong
The First Affiliated Hospital of Shantou University Medical College
Outcome results
None listed