Gastrointestinal Tumor Surgery
Conditions
Interventions
Esketamine Group:During anesthesia maintenance, esketamine was administered intravenously at a dose of 0.1 mg/(kg·h).
Normal saline group:Intraoperative continuous infusion of normal saline
Sponsors
Shanxi Bethune Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60–80 years; 2. American Society of Anesthesiologists (ASA) physical status class II–III; 3. Body mass index (BMI) 18.5–30 kg/m²; 4. Patients scheduled for elective laparoscopic gastrointestinal tumor resection under general anesthesia; 5. Patients who had signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to esketamine; 2. Gastrointestinal motility disorders; 3. History of abdominal surgery; 4. Patients with a history of neurodegenerative diseases (such as Alzheimer’s disease and Parkinson’s disease); 5. Patients with a history of alcoholism, long-term use of antidepressants, mental disorders, or communication disorders; 6. Patients with severe arrhythmia or severe hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Athens Insomnia Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| I-FEED scoring system;Time to first postoperative flatus and defecation;VAS pain score;15-item Quality of Recovery Score;Intraoperative consumption of propofol and remifentanil;Time to awakening and time to extubation;Consumption of opioids in the postoperative analgesic pump;Incidence of adverse reactions, including postoperative delirium, nightmares, hallucinations, dizziness, drowsiness, nausea and vomiting, and pruritus.; | — |
Countries
China
Contacts
Public ContactZhang Jianwen
Shanxi Bethune Hospital
Outcome results
None listed