Postoperative Gastrointestinal Function Recovery
Conditions
Interventions
The group treated with norepinephrine/doxepin:None
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for liver resection surgery under general anesthesia; 2. Age >= 18 years old; 3. ASA grade I - III; 4. Need to use vasoactive drugs due to hemodynamic fluctuations during the operation; 5. Complete anesthesia records available; 6. Obtained written informed consent from the patients.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Simultaneous use of norepinephrine and desoxynorepinephrine during the operation; 3. Continuous or repeated use of other vasoactive drugs that may significantly affect visceral perfusion or gastrointestinal motility (such as dopamine, epinephrine, etc.) during the operation; 4. Death due to any cause within 24 hours after the operation; 5. Hospital stay after the operation <= 3 days; 6. Severe renal insufficiency or requiring dialysis; 7. Severe liver insufficiency; 8. Preoperative presence of intestinal obstruction, active inflammatory bowel disease, abdominal infection, etc.; 9. Long-term use of opioid drugs; 10. Unwilling or unable to cooperate in completing the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of the composite endpoint of "tolerance of solid food and having had defecation " within 96 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first flatus;Time to first defecation;Time to first tolerance of oral intake;Time to first tolerance of solid food;Time to first ambulation;Incidence of postoperative nausea and vomiting;Postoperative pain scores;Postoperative analgesic consumption;Occurrence of perioperative adverse events;First postoperative routine blood test results; | — |
Countries
China
Contacts
Public ContactBo Fang
The First Hospital of China Medical University
Outcome results
None listed