Schizophrenia
Conditions
Interventions
Schizophrenia Group:None
Healthy Control Group:None
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Schizophrenia group: (1) Meets the DSM-5 diagnostic criteria for schizophrenia; (2) Aged 18 to 65 years; (3) Han ethnicity; (4) Right-handed; (5) A PANSS P2 item score >= 4; (6) No language impairment or hearing impairment; (7) Unmedicated or currently taking second-generation antipsychotics other than clozapine. 2.Healthy control group: (1) No history of mental disorders; (2) Aged 18 to 65 years; (3) Han ethnicity; (4) Right-handed; (5) No language impairment or hearing impairment; (6) Negative family history of mental disorders.
Exclusion criteria
Exclusion criteria: 1.Schizophrenia group: (1) Non-native speakers of Chinese; (2) Comorbid with other mental disorders; (3) Currently undergoing MECT; (4) A history of brain injury, neurological disease, or severe physical illness; (5) Intellectual disability, dementia, or comorbid substance dependence and drug abuse; (6) Pregnant or lactating women; (7) Claustrophobia, metal implants, or any other condition making magnetic resonance imaging intolerable. 2.Healthy control group: (1) Non-native speakers of Chinese; (2) A history of brain injury, neurological disease, or severe physical illness; (3) Intellectual disability, dementia, or comorbid substance dependence and drug abuse; (4) Pregnant or lactating women; (5) Claustrophobia, metal implants, or any other condition making magnetic resonance imaging intolerable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of glutamate and other neuro-metabolites;Inter-brain synchrony indicators;brain activation indicators during tasks;Behavioral indicators of linguistic alignment;Brain structure; | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS scores and reduction rate;TLC total score; | — |
Countries
China
Contacts
Public ContactDong Wentian
Peking University Sixth Hospital
Outcome results
None listed