cholecystitis
Conditions
Interventions
Remimazolam Induction and Maintenance Group (Group R):Anesthesia induction was performed with intravenous injection of sufentanil (0.50 µg/kg), cisatracurium besilate (0.15 mg/kg) and remimazolam besy
Propofol Circumfusion Induction and Maintenance Group (Group H):Anesthesia induction was performed with intravenous injection of sufentanil (0.50 µg/kg), cisatracurium besilate (0.15 mg/kg) and ciprof
Sponsors
Ningxia Hui Autonomous Region People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. Patients scheduled for elective laparoscopic cholecystectomy; 3. Body mass index (BMI) 18–25 kg/m²; 4. Signed informed consent form; 5. American Society of Anesthesiologists (ASA) physical status classification ?–?.
Exclusion criteria
Exclusion criteria: 1. Patients with pre-existing cardiovascular diseases; 2. Hypersensitivity to benzodiazepines or ciprofol; 3. Segmental ventricular wall motion abnormalities; 4. Hepatic or renal insufficiency; 5. Difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| left ventricular ejection fraction (LVEF); | — |
Secondary
| Measure | Time frame |
|---|---|
| Ejection fraction difference;Rate of change of ejection fraction;heart rate;Systolic Blood Pressure ;diastolic blood pressure;Mean Arterial Pressure;Rate-pressure product;cardiac output;Left ventricular short-axis systolic function;Stroke volume;Left ventricular end-diastolic diameter (LVEDD);Left ventricular end-systolic diameter (LVESD);End-diastolic volume (EDV);End-systolic volume (ESV);The respective drug doses required when the BIS value decreases to 60;The doses of remimazolam and ciprofol required at the time of intraoperative drug discontinuation;BIS values at T1-T4; | — |
Countries
China
Contacts
Public ContactHai Kerong
Ningxia Hui Autonomous Region People's Hospital
Outcome results
None listed