Immune imbalance in infants and young children
Conditions
Interventions
Colostrum group:None
Transitional milk group:None
Mature milk group:None
Sponsors
Wuxi Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Postpartum status: Postpartum time met the grouping requirements of this study, that is, can provide breast milk 0-5 days postpartum (colostrum), 6-15 days postpartum (transitional milk), or 16 days postpartum and more (mature milk). 2) Health status: singleton, full-term (37-42 weeks of gestation) delivery, no major chronic diseases (e.g., diabetes, cardiovascular disease), active infectious diseases (e.g., HIV, viral hepatitis), or autoimmune diseases. 3) Lactation status: voluntary breastfeeding without acute mastitis or other breast diseases that may significantly affect milk composition. 4) Informed consent: fully understand the purpose, process and rights and interests of the study, and voluntarily sign a written informed consent. 3) Lactation Status: Willingness to breastfeed. No acute mastitis or other breast conditions that could significantly affect the composition of breast milk. 4) Informed Consent: Full understanding of the research purpose, procedures, and rights, and voluntary signing of a written informed consent form.
Exclusion criteria
Exclusion criteria: 1) Maternal Illness/Medication: Recent use (e.g., within one week before or after delivery) of medications that may affect the composition of breast milk (e.g., high-dose hormones, immunosuppressants, etc.). 2) Infant Condition: The infant is diagnosed with a major congenital disease, an inherited metabolic disorder, or requires long-term treatment in the neonatal intensive care unit (NICU). 3) Other Factors: Any other conditions judged by the researcher that might affect the representativeness of the samples or increase the risk associated with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteomics/Peptidomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biological pathways enriched by differential peptides; | — |
Countries
China
Contacts
Public ContactRenqiang Yu
Wuxi Maternal and Child Health Hospital
Outcome results
None listed