People with high levels of anxiety.
Conditions
Interventions
Nasal spray of oxytocin group (high-frequency intake):Take 24IU of oxytocin by nasal spray every day for five consecutive days
Nasal spray of oxytocin group (low-frequency intake):During the 5-day nasal spray intake, 24IU of oxytocin was administered on the first, third and fifth days, while a placebo (normal saline) was take
Placebo group:Nasal spray of normal saline (21IU) for five consecutive days
Sponsors
Institute of Brain and Psychological Science, Sichuan Normal University
Eligibility
Sex/Gender
Female
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: To be eligible for inclusion, participants must meet the following criteria: (1) Female individuals aged 18 to 30 years. (2) Have trait anxiety scores above 45 on the State-Trait Anxiety Inventory (STAI). (3) Demonstrate comprehension of the study's purpose and willingly sign the informed consent form. (4) Be able to cooperate in completing the study procedures, including behavioral assessments, questionnaire measures, and brain imaging scans.
Exclusion criteria
Exclusion criteria: (1) Individuals with a history of bipolar disorder, schizophrenia, substance abuse, or other severe mental disorders; (2) Those at a high risk of suicide; (3) Individuals with neurological disorders such as epilepsy, traumatic brain injury, or Parkinson's disease. (4) Presence of severe cardiovascular diseases, significant liver or kidney dysfunction, thyroid disorders, or other physical conditions that may impact the safety of the study or the interpretation of results; (5) Women who are pregnant or breastfeeding; (6) Use of antidepressants, anti-anxiety medications, steroids, or nasal spray medications within the past 4 weeks. (7) Have participated in other clinical trials in the past 3 months; (8) Other circumstances where the researcher deems unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| State trait anxiety score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotional picture behavior assessment score;Resting-state brain imaging network indicators;Task-state brain imaging index; | — |
Countries
China
Contacts
Public ContactJuan Kou
Institute of Brain and Psychological Science, Sichuan Normal University
Outcome results
None listed