(Postoperative Sleep Disturbance, POSD)
Conditions
Interventions
Experimental Group (Ciprofol Group, Group C):Induction: Intravenous injection of ciprofol 0.4 - 0.5 mg/kg.
Maintenance: Continuous infusion of ciprofol at 0.8 - 3.0 mg/(kg·h).
Control Group (Propofol Group, Group P):Induction: Intravenous injection of propofol 1.5 - 2.5 mg/kg.
Maintenance: Continuous infusion of propofol at 4.0 - 12.0 mg/(kg·h).
Sponsors
Baiyun Hospital Affiliated to Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age: 65 - 85 years 2. Gender: No restriction 3. Physique: Body Mass Index (BMI) 18 - 30 kg/m² 4. Physical Status Classification: American Society of Anesthesiologists (ASA) Grade II - III 5. Surgical Requirements: Expected surgery duration >=2 hours. Anticipated postoperative hospital stay for observation >=3 days. 6. Informed Consent: The patient and/or legal guardian must provide signed informed consent. The patient must be able to cooperate with wearing the sleep monitoring device and completing scale assessments.
Exclusion criteria
Exclusion criteria: 1. Pre-existing Sleep Disorders: History of diagnosed severe sleep disorders (e.g., severe insomnia, untreated severe Obstructive Sleep Apnea (OSA)). 2. Medication Interference: Long-term use of sedative-hypnotics (e.g., benzodiazepines), antidepressants, or corticosteroids within 3 months prior to surgery. 3. Neuropsychiatric History: History of stroke, Alzheimer's disease, Parkinson's disease, or schizophrenia. 4. Specific Habits: History of transmeridian travel (within the past week) or long-term night shift work (indicative of circadian rhythm disruption). 5. Severe Comorbidities: Severe hepatic or renal insufficiency (Child-Pugh Class C or creatinine clearance <30 ml/min). 6. Allergies/Contraindications: Known allergy to soybean oil, eggs, dairy products, or any component of propofol/ciprofol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Sleep Efficiency, SE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Architecture Parameters;Circadian Rhythm and Molecular Mechanism Metrics;Clinical Prognostic Indicators; | — |
Countries
China
Contacts
Public ContactLiu Jiming
Baiyun Hospital Affiliated to Guizhou Medical University
Outcome results
None listed