Pain after lung surgery
Conditions
Interventions
Trial Group:0.665% Bupivacaine Liposome 40mL (mixed from 20mL 266mg bupivacaine liposome and 20mL normal saline) for RISS plane block
Control Group:0.375% Ropivacaine 40mL for RISS plane block
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years and <= 65 years, gender unlimited; 2. Body Mass Index (BMI) 18-30 kg/m^2; 3. Patients scheduled for elective three-port video-assisted thoracoscopic segmentectomy (lobectomy) under general anesthesia, performed by the same surgical team, with expected surgery duration within 4 hours; 4. ASA physical status classification II-III; 5. Possess certain understanding and communication abilities, fully understand the nature, significance, potential benefits, possible inconveniences, and potential risks of the trial before the study, understand the research procedures, and voluntarily sign the informed consent form in writing;
Exclusion criteria
Exclusion criteria: 1.Relative contraindications of general anesthesia: patients with severe heart and lung function diseases; 2.patients with a history of mental illness or long-term use of psychotropic drugs (dementia, schizophrenia), chronic analgesics, alcohol abuse, or cognitive impairment; 3.diabetic patients with severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macroangiopathy, diabetic nephropathy); 4.patients with severe infection; 5.those who were known to be allergic to the test drugs; 6.Unable to cooperate with the test, patients or family members refused the participant; 7.Deformity and infection at the puncture site are not conducive to nerve block operation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption within 72 hours after surgery (converted to morphine equivalent); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative NRS score (resting and movement pain scores);Hemodynamic fluctuations during surgery and postoperatively;Intraoperative dosage of sufentanil, remifentanil, and propofol;Time to extubation and ICU stay duration after surgery;Time to first demand for patient-controlled analgesia pump after surgery;Time to first flatus and defecation, and time to first ambulation after surgery;Incidence of postoperative nausea and vomiting and use of antiemetic drugs;Incidence of complications including pruritus, perioperative hypertension, bradycardia, tachycardia, delayed emergence, dizziness, and delirium within 72 hours after surgery;Sleep quality on nights D0, D1, and D2 after surgery;QoR-15 score assessed on postoperative day 1, day 3, and day of discharge;Hospital length of stay and hospitalization costs (anesthesia cost / total hospitalization cost);Safety outcomes including incidence of local anesthetic adverse events (e.g., metallic taste in mouth, tinnitus, lip numbness), incidence of nerve block-related adverse events (e.g., injection site pain, infection, pneumothorax, local hematoma), serious adverse events (SAEs), and assessment of adverse event causality; | — |
Countries
China
Contacts
Public ContactChen Shibiao
The First Affiliated Hospital of Nanchang University
Outcome results
None listed