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Effect of Esketamine Combined with Epidural Alkalinized Lidocaine in Painless Labor Converted to Emergency Cesarean Section

Effect of Esketamine Combined with Epidural Alkalinized Lidocaine in Painless Labor Converted to Emergency Cesarean Section

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600121948
Enrollment
Unknown
Registered
2026-04-07
Start date
2023-09-22
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstetric Anesthesia

Interventions

Control group:The parturient was brought into the operating room. Examination confirmed that the epidural catheter was intact and not dislodged. Standard ECG monitoring was applied. An alkalinized lid
Trial group:The parturient was brought into the operating room. Examination confirmed that the epidural catheter was in place without dislodgement. Standard ECG monitoring was applied. An alkalinized

Sponsors

Nanhai District Maternal and Child Health Hospital of Foshan City (Nanhai Maternity Children's Hospital, Guangzhou University of Traditional Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Parturients requiring immediate category 1 cesarean section due to obstetric emergencies, who still experienced pain at the skin incision test before surgery; 2. Gestational age >=37 weeks; 3. Estimated fetal weight >=2.5 kg; 4. Successful placement of an epidural catheter at the L2–3 interspace during labor without technical difficulty; 5. Satisfactory labor analgesia (visual analogue scale [VAS] score of 1–2); 6. Fetal heart rate >=120 beats/min at the last assessment before conversion to surgery; 7. American Society of Anesthesiologists (ASA) physical status I–II; 8. No significant abnormalities on routine prenatal examinations.

Exclusion criteria

Exclusion criteria: 1. Presence of cardiovascular disease; 2. Recent use of analgesic medications; 3. Psychiatric disorders preventing cooperation; 4. Hypertension; 5. Conversion to general anesthesia or need for repeat neuraxial puncture due to inadequate anesthetic effect; 6. Conversion to vaginal delivery after entering the operating room; 7. Time interval exceeding 5 minutes from the first epidural bolus of high-concentration local anesthetic to skin incision; 8. Use of vasoactive drugs to treat hypotension or bradycardia.

Design outcomes

Primary

MeasureTime frame
Maternal blood pressure;

Secondary

MeasureTime frame
Is there any pain;Ramsay Sedation Score.;Neonatal Apgar score;Maternal heart rate;Maternal oxygen saturation;Whether the surgeon is satisfied with the degree of muscle relaxation;

Countries

China

Contacts

Public ContactZhai Liping

Nanhai District Maternal and Child Health Hospital of Foshan City (Nanhai Maternity Children's Hospital, Guangzhou University of Traditional Chinese Medicine)

baby060610295@163.com+86 181 2875 3986

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026