Cardiorenal Syndrome
Conditions
Sponsors
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years, no gender restrictions; 2. Meets the diagnostic criteria for CRS (as outlined in the 2021 Clinical Practice Guidelines for the Diagnosis and Treatment of Cardiorenal Syndrome issued by the Division of Nephrology of the Chinese Medical Doctor Association and the 2019 American Heart Association Scientific Statement on Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: Scientific Statement of the American Heart Association"): Patients must have an estimated glomerular filtration rate (eGFR) 133 µmol/L, and NT-proBNP >=1200 ng/L; 3. T2D diagnosis follows the Chinese Diabetes Prevention and Treatment Guidelines 2024 Edition: Typical symptoms (polydipsia, polyphagia, polyuria, weight loss) + random blood glucose >=11.1 mmol/L, or fasting blood glucose>=7.0 mmol/L, or OGTT 2h glucose >=11.1 mmol/L, or HbA1c >=6.5%; Patients without typical symptoms require confirmation via follow-up testing; 4. Patients in retrospective studies must have suitable biological specimens on file; 5. Ethical approval for the use of medical records and biological specimens.
Exclusion criteria
Exclusion criteria: 1. Familial hypercholesterolemia and hypertriglyceridemia; 2. Type 1 diabetes and secondary diabetes; 3. Primary liver disease with transaminase levels more than three times elevated; 4. Patients undergoing continuous hemodialysis; 5. Concurrent severe infection, acute cardiovascular or cerebrovascular disease, uncontrolled thyroid disease, malignancy, or primary severe anemia (Hb < 60 g/L); 6. Pregnant or lactating women; 7. Individuals with psychiatric disorders unable to cooperate with data collection and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age;Gender;Course of disease;Body Mass Index;Systolic Blood Pressure;Diastolic Blood Pressure;Fasting Plasma Glucose;Glycated Hemoglobin;Total Cholesterol;Triglyceride;High-Density Lipoprotein Cholesterol;Low-Density Lipoprotein Cholesterol;N-Terminal Pro-B-Type Natriuretic Peptide;Blood Urea Nitrogen;Serum Creatinine;estimated Glomerular Filtration Rate;High-Sensitivity C-Reactive Protein;oxidized Low-Density Lipoprotein;Ceramides;Glutathione Peroxidase 1;F2a8-Isoprostaglandin F2a;Epicardial Fat Thickness;Podocalyxin;Fasting Insulin;Homeostasis Model Assessment of Insulin Resistance;Urine Protein;Urine Microalbumin;Urine Microalbumin Creatinine Ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Smoking history;Drinking history;Family history;Heart Rate;Lipoprotein a;Apolipoprotein A;Apolipoprotein B; | — |
Countries
China
Contacts
Public ContactZhou YuPing
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed