Acute kidney injury
Conditions
Interventions
Group C(Active Comparator):Induction: propofol 1 mg/kg IV
Maintenance: propofol 3-6 mg/kg/h continuous infusion
Group R1(Experimental group):Induction: remimazolam 0.2 mg/kg IV
Group R2(Experimental group):Induction: propofol 1 mg/kg IV
Maintenance: remimazolam 0.8-2 mg/kg/h continuous infusion
Group R3(Experimental group):Induction: remimazolam 0.2 mg/kg IV
Maintenance:remimazolam 0.8-2 mg/kg/h continuous infusion
Sponsors
The Third Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Patients undergoing elective laparoscopic radical nephrectomy (LRN) under general anesthesia in our hospital; 2 Aged 45 to 80 years; 3 Classified as American Society of Anesthesiologists (ASA) physical status ?–?; 4 With normal preoperative cardiac, hepatic, and renal function; 5 Patients or their legally authorized representatives have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1 Patients who have used nephrotoxic drugs within 3 months prior to surgery; 2 Patients with a history of secondary renal surgery; 3 Patients with a history of severe infection, shock, or other conditions requiring emergency resuscitation prior to surgery; 4 Patients who develop major complications during or after surgery, such as severe cardiovascular or cerebrovascular events or massive hemorrhage; 5 Patients with known allergies to the anesthetic agents used in the study (including remimazolam).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine;Aggregate Index of Systemic Inflammation;Hemoglobin, Albumin, Lymphocyte, and Platelet Score;Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio;Neutrophil to Lymphocyte Ratio;C-reactive protein - Albumin - Lymphocyte Index;Advanced Lung Cancer Inflammation Index;Systemic Inflammation Response Index;Inflammatory Burden Index;Gamma-glutamyl transferase;Pan-Immune-Inflammation Value;Hemoglobin to Red Blood Cell Distribution Width Ratio;Atherogenic Index of Plasma;Neutrophil Percentage to Albumin Ratio;Creatinine-to-Cystatin C Ratio;Systemic Immune-Inflammation Index;Platelet to Lymphocyte Ratio;Lymphocyte to Monocyte Ratio;Systemic Inflammation Response Index;Red Blood Cell Distribution Width to Albumin Ratio;Bilirubin-to-Albumin Ratio;White Blood Cell to High-Density Lipoprotein Cholesterol Ratio;Lymphocyte to High-Density Lipoprotein Cholesterol Ratio;Platelet-to-High-Density Lipoprotein Cholesterol Ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil;Platelet;Lymphocyte;Monocyte;C-reactive protein;Hemoglobin;Uric Acid;High-Density Lipoprotein Cholesterol;Glomerular Filtration Rate;Red Blood Cell Distribution Width;Triglycerides;Neutrophilic granulocyte percentage;Percentage of lymphocyte;Cystatin C;Homocysteine;White blood cell;Glucose;Albumin;Total Bilirubin;Surgery time;Total Volume Infused;Estimated Blood Loss;Age;Body Mass Index;Gender;Urine output after the surgery;Hypertension;Diabetes mellitus; | — |
Countries
China
Contacts
Public ContactYongzhe Liu
The Third Medical Center of Chinese PLA General Hospital
Outcome results
None listed