delirium
Conditions
Interventions
Experimental group:The experimental group was treated with HA380 hemoperfusion device during cardiopulmonary bypass
Control group:The control group received conventional cardiopulmonary bypass
Sponsors
The Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Planned elective cardiac surgery, with an expected CPB duration > 90 minutes; 3. Preoperative MMSE score: Illiterate > 17 points, Primary school level > 20 points, Secondary school level (including technical secondary school) > 22 points, University level (including junior college) > 23 points; 4. Patients who understand this study and agree to sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Preoperative MMSE scores: illiterate <=17 points, primary school level <=20 points, secondary school level (including technical secondary school) <=22 points, university level (including college) <=23 points; 2. Patients with drug or psychiatric medication abuse, severe mental illnesses, coagulation or immune dysfunctions, severe liver, kidney, lung, or brain diseases, those undergoing secondary or emergency cardiac surgery, or those with severe vision or hearing impairments who cannot cooperate with testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-2;IL-4;IL-6;IL-10;TNF-a;IL-?;C-reactive protein (CPR);Procalcitonin (PCT);Alanine transaminase (ALT);Aspartate transaminase (AST);Creatinine (Cr);Duration of postoperative delirium;Postoperative complications;Length of ICU hospital stay;Duration of mechanical ventilation;Extubation rate within 1 hour after operation;Length of hospital stay;Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactYun Ren
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed